• Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects

    1 month ago - By Pediatric Critical Care Medicine

    Objectives: Congenital heart disease with increased pulmonary blood flow results in progressive pulmonary vascular endothelial dysfunction and associated increased perioperative morbidity. Using our ovine model of congenital heart disease with increased pulmonary blood flow, we have previously demonstrated progressive endothelial dysfunction associated with disruption in carnitine homeostasis, mitochondrial dysfunction, decreased nitric oxide signaling, and enhanced reactive oxygen species generation. However, potential alterations in these parameters in patients with congenital heart...
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  • Here's Why Maternal Diabetes Increases Risk of Congenital Heart Defects

    Here's Why Maternal Diabetes Increases Risk of Congenital Heart Defects

    1 month ago - By Medindia Health

    The risk for congenital heart defects in children increases with disruption of Nitric Oxide and Notch1 signaling pathways in maternal diabetes.
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