Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects
1 month ago - By Pediatric Critical Care Medicine
Objectives: Congenital heart disease with increased pulmonary blood flow results in progressive pulmonary vascular endothelial dysfunction and associated increased perioperative morbidity. Using our ovine model of congenital heart disease with increased pulmonary blood flow, we have previously demonstrated progressive endothelial dysfunction associated with disruption in carnitine homeostasis, mitochondrial dysfunction, decreased nitric oxide signaling, and enhanced reactive oxygen species generation. However, potential alterations in these parameters in patients with congenital heart...
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Here's Why Maternal Diabetes Increases Risk of Congenital Heart Defects
1 month ago - By Medindia Health
The risk for congenital heart defects in children increases with disruption of Nitric Oxide and Notch1 signaling pathways in maternal diabetes.
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The headlines of Master Doctor
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Babies as old as 10 months old can determine the value of a goal by observing people as to how hard they work to achieve that goal.
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The findings from the Virginia Commonwealth University highlight the direct implications the current obesity epidemic could have on the generations to come.
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A diagnostic test was identified to detect biliary atresia in children to avoid liver transplantation. This disease is the top cause of liver transplant in kids.