• Cholesterol-lowering gene changes may increase the risk of cataracts

    17 days ago - By ScienceDaily

    Researchers used large-scale genotyping and exome sequencing from the UK Biobank to gain insight into the expected effects of long-term statin use on cataract risk. The analysis found that common genetic variants in more than 402,000 people, who were not taking statins, that mimic the effects of LDL-cholesterol lowering statins are associated with a higher risk of cataracts and cataract surgery. They also found that rare genetic mutations in 169,172 people, mimicking statin treatment, increased the risk of developing cataracts by nearly five times.
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  • Genetic HMG-CoA reductase inhibition may raise cataract risk

    Genetic HMG-CoA reductase inhibition may raise cataract risk

    18 days ago - By Healio

    Genetic inhibition of HMG-CoA reductase, a state that mimics long-term statin use, was associated with greater risk for developing cataract compared with individuals without genetic inhibition, researchers reported.
    According to data published in the Journal of the American Heart Association, individuals with an especially rare variant of genetic HMG-CoA reductase inhibition experienced a fivefold risk for developing cataract and undergoing cataract surgery, compared with noncarriers of the variant.
    “We were able to establish a link between genetic variants that mimic inhibition of HMGCR
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