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Polygenic risk score does not improve prediction of aggressive prostate cancer
13 days ago - By Healio
A prostate cancer polygenic risk score did not better predict the risk for aggressive disease compared with a clinical risk predictor and may not be clinically useful, according to study results published in JAMA Internal Medicine.
Currently, prostate cancer screening instruments commonly end up with patients undergoing biopsies that find either no cancer or cancer that is clinically insignificant, Kerry R. Schaffer, MD, MSCI, an assistant professor at Vanderbilt University, and colleagues wrote.
But there is some interest in using a polygenic risk score, which can measure “the burden of
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