• Dietary Selenium Requirement for the Prevention of Glucose Intolerance and Insulin Resistance in Middle-Aged Mice

    12 days ago - By Nutrition

    ABSTRACTBackgroundAlthough dietary selenium deficiency or excess induces type 2 diabetes-like symptoms in mice, suboptimal body Se status usually causes no symptoms but may promote age-related decline in overall health.ObjectivesWe sought to determine the dietary Se requirement for protection against type 2 diabetes-like symptoms in mice.MethodsThirty mature male C57BL/6J mice were fed a Se-deficient torula yeast AIN-93M diet supplemented with Na 2 SeO 4 in graded concentrations totaling 0.01 , 0.04, 0.07, 0.10, and 0.13 mg Se/kg for 4 mo until they were middle-aged. Droplets of whole...
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