• High-dose buprenorphine safe, well-tolerated in opioid users

    1 month ago - By Healio

    Patients with untreated opioid use disorder responded well to a high-dose induction of buprenorphine in the ED, results of a case series in JAMA Network Open showed.
    The Substance Abuse Mental Health Services Administration recommends in its buprenorphine induction guidance that patients start at 2 mg to 4 mg followed by a second dose 2 hours later, with a maximum dose of 8 mg to 12 mg on day 1 and 16 mg on day 2, according to Andrew A. Herring, MD, of the department of emergency medicine at Highland Hospital-Alameda Health System and the University of California, San Francisco, and
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