• The perils of using predicted values in place of observed covariates: an example of predicted values of body composition and mortality risk

    5 days ago - By American Journal of Clinical Nutrition

    ABSTRACTBackgroundSeveral studies have assessed the relation of body composition to health outcomes by using values of fat and lean mass that were not measured but instead were predicted from anthropometric variables such as weight and height. Little research has been done on how substituting predicted values for measured covariates might affect analytic results.ObjectivesWe aimed to explore statistical issues causing bias in analytical studies that use predicted rather than measured values of body composition.MethodsWe used data from 8014 adults ≥40 y old included in the 1999-2006 US...
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