• Belimumab after rituximab reduces IgG anti-dsDNA antibody levels, flare risk in lupus

    3 days ago - By Healio

    Belimumab after rituximab reduces serum IgG anti-double-stranded DNA antibody levels and the risk for severe flare in systemic lupus erythematosus refractory to conventional therapy, according to data.
    “Over the past 20 years, B-cell depletion with rituximab, a chimeric anti-CD20 monoclonal antibody, has shown benefit in open-label studies, but 2 large phase 3, double-blind, randomized, placebo-controlled trials in nonrenal lupus and renal lupus did not find statistically significant differences for their primary end points,” Michael R. Ehrenstein, MBBS, PhD, of University College
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