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FDA's acetaminophen-opioid mandate linked to reductions in acute liver failure
13 days ago - By Healio
Ate to 5.3% in 2019.
An FDA mandate limiting acetaminophen in medications combining acetaminophen and opioids was associated with a reduction in serious liver injuries, a recent study in JAMA found.
According to Babak J. Orandi, MD, PhD, MSc, an assistant professor of surgery at the University of Alabama at Birmingham, and colleagues, the mandate - first introduced by the FDA in 2011 and requiring compliance by 2014 - enforced a maximum acetaminophen dose of 325 mg per tablet in acetaminophen-opioid products.
“Prior to the mandate, formulations contained 325 to 750 mg of
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