• SARS-CoV-2 variants emerge during humoral immunity phase of acute COVID-19

    1 day ago - By News Medical

    A new preprint research paper posted to the bioRxiv server reports the rapid emergence of variants within an infected individual. The evolution of the virus within an infected host is not excluded by the close similarity between the consensus sequences of single-person SARS-CoV-2, since the number of viral copies is at its peak soon after infection occurs and before the host develops adaptive immunity.
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  • Research predicts which mammal species can spread SARS-CoV-2

    1 day ago - By News Medical

    Scientists worldwide are fighting to contain the ongoing COVID-19 pandemic, which has already claimed more than 2.48 million lives. Preventing spillback infections is essential to containing the pandemic. To do so, it is vital to understand the nature of the virus, i.e., its susceptibility to a range of hosts.
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  • Key mutation sites in the SARS-CoV-2 spike protein modulate antibody and ACE2 affinity

    1 day ago - By News Medical

    A paper recently uploaded to the preprint server bioRxiv by researchers at Chapman University in California utilized computational methods to screen severe acute respiratory syndrome coronavirus 2 mutants for affinity with the angiotensin-converting enzyme 2 receptor and monoclonal antibodies REG10987 and REG10933.
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  • SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

    1 day ago - By News Medical

    A new research paper recently uploaded to the preprint server bioRxiv by Jesse D. Bloom et al. aims to map all of the currently circulating SARS-CoV-2 lineages with resistance towards LY-CoV555 and LY-CoV016, and document the specific mutations that confer resistance, ultimately suggesting that future monoclonal antibody cocktails should target a more diverse range of epitopes.
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  • GSK-3 inhibitors show promise in treating coronavirus infections

    1 day ago - By News Medical

    Researchers in the United States have suggested a new approach to treating infection with coronaviruses such as severe acute respiratory syndrome coronavirus 2 - the agent that causes coronavirus disease 2019 .
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  • Glycan switch may explain why SARS-CoV-2 causes such variable symptoms

    1 day ago - By News Medical

    Researchers in Portugal have provided evidence that might explain why infection with severe acute respiratory syndrome coronavirus 2 causes mild or even asymptomatic illness in some individuals, but severe coronavirus disease 2019 in others.
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