• Timing Neonatal Hypoxic-Ischemic Encephalopathy

    1 day ago - By The Journal of Pediatrics

    Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy initiated within six hours after birth effectively prevents neurodevelopmental impairments in some but not all infants. In part, this may be related to the timing of hypoxia before birth relative to the initiation of cooling. Metabolic acidosis at birth is required for treatment with hypothermia. However, placental evidence suggests that some infants also have chronic hypoxemia or poor perfusion before birth.
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