• Dietary Cyanidin-3-Glucoside Attenuates High-Fat-Diet-Induced Body-Weight Gain and Impairment of Glucose Tolerance in Mice via Effects on the Hepatic Hormone FGF21

    1 month ago - By Nutrition

    ABSTRACTBackgroundDietary polyphenols including anthocyanins target multiple organs.ObjectiveWe aimed to assess the involvement of glucagon-like peptide 1 , leptin, insulin and fibroblast growth factor 21 in mediating metabolic beneficial effects of purified anthocyanin cyanidin-3-glucoside .MethodsIntestinal proglucagon gene and liver Fgf21 expression were assessed in 6-wk-old male C57BL-6J mice fed a low-fat-diet , alone or with 1.6 mg Cy3G/L in drinking water for 3 wk. Similar mice were fed the LFD or a high-fat diet with or without Cy3G for 20 wk. Half of the mice administered Cy3G...
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