• Lactoferrin Is a Potential Activator of the Vitamin D Receptor in Its Regulation of Osteogenic Activities in C57BL/6J Mice and MC3T3-E1 Cells

    28 days ago - By Nutrition

    ABSTRACTBackgroundLactoferrin has been shown to promote bone anabolism, and the vitamin D receptor mediates the effects of vitamin D on bone. We hypothesized that LF improves bone health by increasing VDR expression.ObjectivesWe sought to determine the role of VDR activation in LF-induced osteogenic activity in vivo and in vitro and the underlying molecular mechanisms.MethodsSixty male C57BL/6J mice were randomly assigned into 6 groups and fed vitamin D-deficient or vitamin D-normal diet and administered placebo or LF by gavage for 24 wk. Trabecular bone structure was analyzed using...
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