• Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity

    12 days ago - By Nutrition

    ABSTRACTBackgroundObesity, a major public health problem worldwide, is associated with dysfunction of the intestinal barrier. Glycine has been reported to enhance the expression of tight-junction proteins in porcine enterocytes. It is unknown whether Gly can improve intestinal barrier integrity in obese mice.ObjectivesThis study tested the hypothesis that Gly enhances the intestinal epithelial barrier by regulating endoplasmic reticulum stress-related signaling and mitigating inflammation in high-fat diet -induced obese mice.MethodsFive-week-old male C57BL/6J mice were fed a normal-fat...
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