• SARS-CoV-2 variant B.1.617 gives the immune system a hard time

    2 days ago - By ScienceDaily

    Researchers have investigated the SARS-CoV-2 variant B.1.617 in detail. In cell culture studies, they found that this variant can infect certain lung and intestinal cell lines more efficiently than the original virus. The researchers also demonstrated that B.1.617 is less sensitive to inhibition by antibodies present in the blood of convalescent or vaccinated individuals and resistant to a therapeutic antibody used for COVID-19 treatment.
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  • Study examines the host and viral factors that drive SARS-CoV-2 evolution

    2 days ago - By News Medical

    In a new paper recently uploaded to the preprint server bioRxiv*, two clinical isolates of SARS-CoV-2 are monitored by whole genome sequencing as they are passaged through several generations of Vero cells or human-derived primary nasal epithelial cells , allowing direct observation of the occurrence of virus enhancing mutations and the way in which host cell factors shape virus evolution.
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  • Intestinal organoids demonstrate variability in SARS-CoV-2 susceptibility

    2 days ago - By News Medical

    Three-dimensional organoid structures grown in the lab allow deeper, almost in situ investigation of a biological system, without the use of living animals. In a paper recently uploaded to the preprint server bioRxiv*, organoids generated from human specimens are utilized to investigate the way in which SARS-CoV-2 interacts with the numerous cells of the intestinal epithelium, finding great heterogeneity in the susceptibility of the organoids and the cells within to infection.
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