• The impact of co-morbidity in childhood cystic fibrosis

    2 monthes ago - By Paediatric Respiratory Reviews

    A number of risk factors have been identified for deterioration of lung disease in children with Cystic Fibrosis , and current management strategies are based on the prevention and treatment of such elements. Further challenge ensues when a patient has co-morbid disease in addition to CF, particularly when faced with rapidly deteriorating pulmonary status. It is difficult to measure the contribution of other pathologies to this decline and optimisation of both CF care and co-morbidity is paramount.
    Read more ...

     

  • Assessment of liver disease in cystic fibrosis

    2 monthes ago - By Paediatric Respiratory Reviews

    Liver disease in cystic fibrosis has many causes, with biliary fibrosis due to abnormal CFTR protein predominating. Assessment requires aetiology to be defined. Biliary fibrosis may progress to cirrhosis and portal hypertension, which although initially asymptomatic, may cause varices and splenomegaly. Monitoring progression includes clinical and ultrasound assessment with endoscopic assessment of varices for those at risk. Extrapolated primarily from longitudinal assessment of viral hepatitis in adults, non-invasive elastography has a potential role.
    Read more ...